Nanotechnology presents An array of opportunities to contribute to biology. Right here I will present examples the place nanofabrication – the opportunity to make confined constructions with Proportions at will – is applied to examine the biophysics of single molecules and cells. I will present some illustrations from our lab:
Our group research bacterial mobile division which is aiming to constitute a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in mobile division, chromatin framework, and spatial Handle.
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study with the dynamics DNA supercoils and the discovery of supercoil hopping
Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: fast electron relay to redox enzymes and zeptomole protein-film voltammetry
You're a Christian. If you may make such a artificial cell, would you be just one stage nearer to God, or would the part of God have diminished somewhat yet again?
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‘The fantastically delicate way during which components in nature functionality under no circumstances ceases to amaze me. If we fix the puzzle of how existence came into remaining, I be expecting that my amazement on the complexity of creation should have enhanced and with it my awe for your greatness from the Creator.’
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2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of to start with logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA maintenance enzymes with AFM
Developments in nanotechnology from the 1990s created creating electronic units from solitary molecules a likelihood. Cees Dekker recounts how his group developed a home-temperature transistor dependant on only one carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments